Study on drug metabolizing enzyme (5) functional relationship between microsomal glucose dehydrogenase and microsomal electron transport system

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منابع مشابه

Hepatic microsomal glucose transport.

1 Turk, E., Zabel, B., Mundlos, S., Dyer, J. and Wright, E. M. (1991) Nature (London) 350, 354-356 2 Hopfer, U. (1987) in Physiology of Gastro-Intestinal Tract (Johnson, L. R., eds.), 2nd edn., pp. 14991526, Raven Press, New York, NY 3 Semenza, G., Kessler, M., Hosang, M. and Schmidt, U. (1984) Biochim. Biophys. Acta 779,343-379 4 Wright, E. M., Hirayama, B., Hazama, A., Loo, D. D. F., Suppliss...

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Microsomal Electron Transport

NADPH-cytochrome c reductase in rat liver microsomes was solubilized by bromelain digestion and purified to homogeneity. An antibody preparation obtained by immunization with this enzyme was found to inhibit the NADPHcytochrome c reductase activity of both the purified enzyme and intact microsomes by more than 90%. This antibody also inhibited the NADPH-dependent peroxidation of microsomal lipi...

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Phenobarbital-induced Synthesis of the Microsomal Drug-metabolizing Enzyme System and Its Relationship to the Proliferation of Endoplasmic Membranes

Liver microsomes, isolated from rats which had been treated with phenobarbital in vivo, were found to exhibit increased activities of oxidative demethylation and TPNH-cytochrome c reductase and an increased amount of CO-binding pigment. Simultaneous administration of actinomycin D or puromycin abolished the phenobarbital-induced enzyme synthesis. Increased rate of P(i) (32) incorporation into m...

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Sex difference in the activities of microsomal drug-metabolizing enzyme systems in relation to dietary protein.

‰Á " ¡ —²ˆê Kato et al. (1-3) and Booth and Gillette (4) demonstrated that the sex difference in the activities of drug-metabolizing enzyme systems of rat liver microsomes is related to the anabolic action of male sex hormone. In fact, they demonstrated increases in the activities of drug-metabolizing enzymes of liver microsomes of castrated female rats by the treatment with synthetic hormones ...

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Parotid microsomal Ca2+ transport

Rat parotid gland homogenates were fractionated into mitochondrial, heavy microsomal and light microsomal fractions by differential centrifugation. ATP-dependent 45Ca2+ uptake by the subcellular fractions paralleled the distribution of NADPHcytochrome c reductase, an enzyme associated with the endoplasmic reticulum. The highest rate of Ca2+ uptake was found in the heavy microsomal fraction. Ca2...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1978

ISSN: 0021-5198

DOI: 10.1016/s0021-5198(19)67285-9